Does Orthodontic Tooth Movement Cause an Elevation in Systemic Inflammatory Markers?
MacLaine et al. tried to answer this question in The European Journal of Orthodontics (2010; 0: cjp108v2-cjp108). The aim of this study was to evaluate the effects of orthodontictreatment on systemic levels of the inflammatory markers, C-reactiveprotein (CRP), tumour necrosis factor-
(TNF-), and interleukin-6(IL-6). The study group comprised 11 girls and 6 boys (meanage 13.1 years) treated with fixed appliances and distalizingheadgear. Venous blood samples were taken from the cubital veinof each subject before treatment (T0) and then at three furthertime points during treatment (T1–T3), 2 months apart.The sera from these blood samples were analysed using enzyme-linkedimmunosorbent assay (ELISA) assay technology for CRP, TNF-,and IL-6 concentration levels. Data were compared between baselineand subsequent sequential time points using a Mann–Whitneytest for non-normally distributed variables.
(TNF-), and interleukin-6(IL-6). The study group comprised 11 girls and 6 boys (meanage 13.1 years) treated with fixed appliances and distalizingheadgear. Venous blood samples were taken from the cubital veinof each subject before treatment (T0) and then at three furthertime points during treatment (T1–T3), 2 months apart.The sera from these blood samples were analysed using enzyme-linkedimmunosorbent assay (ELISA) assay technology for CRP, TNF-,and IL-6 concentration levels. Data were compared between baselineand subsequent sequential time points using a Mann–Whitneytest for non-normally distributed variables.The results showed that there was no significant elevation ofany of the three inflammatory markers at any of the time points.This research provides evidence that conventional orthodontictreatment is not associated with a systemic immune responsein the factors investigated.
Reference:
MacLaine et al.The European Journal of Orthodontics (2010; 0: cjp108v2-cjp108).
