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Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes
ABSTRACT:
 
Background:
There is evidence that reducing blood glucose concentrations, inducing weight loss, and improving the lipid profile reduces cardiovascular risk in people with type 2 diabetes.
 
Objective:
We assessed the effect of various diets on glycemic control, lipids, and weight loss.
 
Design:
We conducted searches of PubMed, Embase, and Google Scholar to August 2011. We included randomized controlled trials (RCTs) with interventions that lasted ≥6 mo that compared low-carbohydrate, vegetarian, vegan, low–glycemic index (GI), high-fiber, Mediterranean, and high-protein diets with control diets including low-fat, high-GI, American Diabetes Association, European Association for the Study of Diabetes, and low-protein diets.
Results: A total of 20 RCTs were included (n = 3073 included in final analyses across 3460 randomly assigned individuals). The low-carbohydrate, low-GI, Mediterranean, and high-protein diets all led to a greater improvement in glycemic control [glycated hemoglobin reductions of −0.12% (P = 0.04), −0.14% (P = 0.008), −0.47% (P < 0.00001), and −0.28% (P < 0.00001), respectively] compared with their respective control diets, with the largest effect size seen in the Mediterranean diet. Low-carbohydrate and Mediterranean diets led to greater weight loss [−0.69 kg (P = 0.21) and −1.84 kg (P < 0.00001), respectively], with an increase in HDL seen in all diets except the high-protein diet.
 
Conclusion:
Low-carbohydrate, low-GI, Mediterranean, and high-protein diets are effective in improving various markers of cardiovascular risk in people with diabetes and should be considered in the overall strategy of diabetes management.
 
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